About the A2CPS Consortium

Acute to Chronic Pain Signatures Program Snapshot

Multisite Clinical Center (MCC)

Location

Webpage

Institute for Translational Medicine

https://chicagoitm.org

Rush University Medical Center

https://www.rush.edu

The University of Chicago Medical Center

https://www.uchicago.edu

NorthShore University HealthSystem

https://www.northshore.org

University of Illinois at Chicago

http://chicago.medicine.uic.edu/departments/centers/center-magnetic-resonance-research/3t-program/

Clinical Coordination Center

Location

Webpage

University of Iowa

https://a2cps.org/about/ui/

Omics Data Generation Centers

Location

Webpage

Pacific Northwest National Laboratory

https://a2cps.org/about/pnnl/

University of California San Diego

https://a2cps.org/about/ucsd/

Wake Forest University

https://a2cps.org/about/wfu/

Data Integration and Resource Center

Location

Webpage

Johns Hopkins University

https://a2cps.org/about/jhu/

Dartmouth College

https://a2cps.org/about/dc/

Texas Advanced Computing Center

https://a2cps.org/about/tacc/


The A2CPS Program has four components. A description of the FOAs and a diagram indicating how the components of the Consortium will interact with each other are listed below:

A Data Integration and Resource Center (DIRC) will integrate the efforts of all funded components of the A2CPS and serve as a community-wide nexus for protocols, data, assay and data standards, and other resources generated by the A2CPS Program. (RFA-RM-18-031)

Three Omics Data Generation Centers (ODGCs) will use cutting edge technologies to perform omics analyses (e.g. metabolomic, lipidomic, proteomic, extracellular RNA) of body fluids collected by the Acute to Chronic Pain Signatures (A2CPS) Consortium. (RFA-RM-18-032)

A Multisite Clinical Center (MCC) will implement the enrollment and multimodal longitudinal assessment of a large cohort of acute peri-operative pain patients (total knee arthroplasty) to identify a biosignature for resilience to and the transition from acute to chronic pain. (RFA-RM-18-034)*

*A second MCC will be funded in 2020, studying a cohort of patients with acute pain associated with either an acute musculoskeletal trauma or a peri-operative pain event. Please see RFA-RM-19-013 for more details.

A Clinical Coordination Center (CCC) will serve as the hub for the Multisite Clinical Centers. The CCC will support study design, efficiency, progress, and quality, will coordinate and monitor study implementation across the clinical sites, and will lead the consortium in developing and implementing protocols and standards. (RFA-RM-18-035)