About the A2CPS Consortium

Acute to Chronic Pain Signatures Program Snapshot

Multisite Clinical Center 1 (MCC1)

Location

Principal Investigator(s)

Webpage

Institute for Translational Medicine

Julian Solway, MD; Lainie Ross, MD, PhD; Joshua Jacobs, MD

http://a2cps.org/consortium/multisite-clinical-center/institute-translational-medicine/

Rush University Medical Center

John Burns, PhD; Asokumar Buvanendran, MD; Joshua Jacobs, M.D.

https://a2cps.org/consortium/multisite-clinical-center/rush-university-medical-center/

The University of Chicago Medical Center

Tessa Balach, M.D.

https://a2cps.org/consortium/multisite-clinical-center/university-chicago-medical-center/

NorthShore University HealthSystem

Richard Wixson, M.D.

https://a2cps.org/consortium/multisite-clinical-center/northshore-university-healthsystem/

University of Illinois at Chicago

Xiaohong Joe Zhou, PhD, DABR

https://a2cps.org/consortium/multisite-clinical-center/university-illinois-chicago/

Multisite Clinical Center 2 (MCC2)

Location

Principal Investigator(s)

Webpage

University of Michigan

Chad Brummett, MD; Dan Clauw, MD; Andrew Chang, MD; Jennifer Waljee, MD

https://a2cps.org/consortium/multisite-clinical-center/university-michigan/

Clinical Coordination Center (CCC)

Location

Principal Investigator(s)

Webpage

University of Iowa

Kathleen Sluka, PhD; Laura Frey Law, PhD; Christopher Coffey, PhD

https://a2cps.org/consortium/clinical-coordination-center/university-iowa/

Omics Data Generation Center (ODGC)

Location

Principal Investigator(s)

Webpage

Pacific Northwest National Laboratory

John Jacobs, Ph.D

https://a2cps.org/consortium/omics-data-generation-center/pacific-northwest-national-laboratory/

University of California San Diego

Louise Laurent, MD/Ph.D

https://a2cps.org/consortium/omics-data-generation-center/university-california-san-diego/

Wake Forest University

Michael Olivier, Ph.D.

https://a2cps.org/consortium/omics-data-generation-center/wake-forest-university/

Data Integration and Resource Center (DIRC)

Location

Principal Investigator(s)

Webpage

Johns Hopkins University

Martin Lindquist, Ph.D

https://a2cps.org/consortium/data-integration-and-resource-center/john-hopkins-university/

Dartmouth College

Tor Wager, Ph.D

https://a2cps.org/consortium/data-integration-and-resource-center/dartmouth-college/

Texas Advanced Computing Center

Ari Kahn, Ph.D

https://a2cps.org/consortium/data-integration-and-resource-center/texas-advanced-computing-center/

The A2CPS Program has four components. A description of the FOAs are listed below.

Data Integration & Resource Center (DIRC)
Will integrate the efforts of all funded components of the A2CPS and serve as a community-wide nexus for protocols, data, assay and data standards, and other resources generated by the A2CPS Program.

RFA-RM-18-031

Omics Data Generation Center (ODGC)
Will use cutting edge technologies to perform omics analyses (e.g. metabolomic, lipidomic, proteomic, extracellular RNA) of body fluids collected by the Acute to Chronic Pain Signatures (A2CPS) Consortium.

RFA-RM-18-032

Multisite Clinical Center (MCC)
Will implement the enrollment and multimodal longitudinal assessment of a large cohort of acute peri-operative pain patients (total knee arthroplasty) to identify a biosignature for resilience to and the transition from acute to chronic pain.

RFA-RM-18-034

Clinical Coordination Center (CCC)
Will serve as the hub for MCCs. The CCC will support study design, efficiency, progress, and quality, will coordinate/monitor study implementation across the clinical sites, and will lead the consortium in developing and implementing protocols and standards.

RFA-RM-18-035