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Primary Biomarkers
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Assessment
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1. General pain intensity
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Brief Pain Intensity -whole body pain
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2. Local pain intensity
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Modified BPI – surgical site pain
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3. Widespread body pain
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Michigan Body Map
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4. Acute pain trajectory following surgery
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Single item assessments of daily pain and/or pain interference during post-surgical period.
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5. Disability
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Knee Injury and Osteoarthritis Outcome Score – 12 (TKA only)
Danish Thoracic Surgery Questionnaire (Thoracic surgery only)
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6. Physical function
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PROMIS Short Form v2.0 Physical Function 8b
Five Times Sit-to-Stand, 10 Meter Walk Test (TKA only)
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7. Movement-evoked pain
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Five Times Sit-to-Stand, 10 Meter Walk Test (TKA only)
Coughing and deep breathing (Thoracic surgery only)
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8. Anxiety
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General Anxiety Disorder – 7
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9. Depressive symptoms
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Patient Health Questionnaire – 8
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10. Pain catastrophizing
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Pain Catastrophizing Scale – 6
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11. Fear of movement
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Fear Avoidance Beliefs Questionnaire – Physical Activity
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12. Sleep
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PROMIS Short Form v1.0 Sleep Disturbance 6a
Sleep duration = time of sleep obtained over the past month
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13. Trauma history
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Adverse Childhood Experience questionnaire
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14. Resilience
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Pain Resilience Scale
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15. Social support
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PROMIS SFv2.0 Instrumental Support 6a
PROMIS SFv2.0 Emotional Support 6a
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16. Cognitive dysfunction
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Multidimensional Inventory of Subjective Cognitive Impairment
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