Artwork by Kathleen Sluka

For most people, pain goes away when an injury heals. But for some people, pain after surgery can linger, and can last for years or even a lifetime. The Acute to Chronic Pain Signatures (A2CPS) project is a bold research initiative - the largest and most comprehensive of its kind - being carried out by a nation-wide consortium of researchers. The findings will help researchers to develop better, more individualized treatments for patients and to better understand the complex biological processes underlying chronic pain.


About A2CPS

Protocol

A2CPS will collect questionnaires, blood samples and brain imaging from 2,800 participants before and for up to 12 months after having total knee replacement or thoracic surgery.

Biomarkers

Many diseases can be diagnosed, tracked and predicted with biological markers, or biomarkers, but none are yet known for chronic pain. The major aim of A2CPS is to find biomarkers or bio-signatures of the transition to chronic pain.

Consortium

The A2CPS consortium is organized into four main hubs, with over 100 investigators and staff around the country. Our researchers span a wide range of expertise, from basic scientists to clinicians to data management experts.

Assessments

In addition to biological specimens, A2CPS also collects different types of data from our participants, including patient-reported outcomes (PROs) and quantitative sensory testing (QST), among others.

Omics from Blood

The term “omics” refers to the collection of information about the molecules found in our blood, which can tell us about the activity of genes, proteins, lipids and metabolites in our cells and tissues.

Brain Imaging

Previous studies have identified “signatures” of brain activity that reflect a painful experience, and others that predicted who was more likely to develop chronic pain. A2CPS will include brain-imaging data in our search for biosignatures of chronic pain.

Latest News


A2CPS Consortium Gathers in Chicago

Published Feb 2024

The A2CPS Consortium will gather in person March 26-27, hosted by Rush University in Chicago. A2CPS investigators are currently analyzing our baseline data, which will become available to researchers via the NIMH Data Archive (NDA) platform in summer 2024. Stay tuned for details. 


AAOS Honors Dr. Joshua Jacobs

Published Feb 2024

A2CPS Investigator Joshua J. Jacobs, MD, FAAOS, was honored by the American Academy of Orthopaedic Surgeons (AAOS) with its 2024 William W. Tipton Jr., MD, Leadership Award, for his years of service to the profession and to his community. Congratulations, Dr. Jacobs!