A2CPS: Acute to Chronic Pain Signatures

Defining biomarkers for the transition from acute to chronic pain

For most people, pain goes away as soon as the injury that caused it heals. For some people, however, acute pain from an injury, surgery, or disease can linger, eventually becoming chronic pain that can last for years or even for a lifetime. Currently, a high proportion of people in the United States transition to chronic pain after an acute pain event, and this has been a contributing factor to the current opioid epidemic.

The Acute to Chronic Pain Signatures (A2CPS) program will collect data from 3,600 people who have recently had surgery or musculoskeletal injury and track them for a 6-month period. The goal is to develop a set of biomarkers, or “signatures”, that can predict whether a person will transition to chronic pain or be resilient. These signatures use measurements, including those from a patient’s genetics, genomics, inflammation, metabolic pathways, brain structure, and brain function. These will be combined with advanced statistical and artificial intelligence approaches to create a measure that predicts whether an individual person is likely to develop chronic pain. This measure will allow researchers to develop better, more individualized treatments for patients and better understand the biological bases of pain.

This initiative is funded through the National Institutes of Health Common Fund, which supports cross-cutting programs that are expected to have exceptionally high impact.

Featured News

A2CPS Consortium Meeting: March 23rd, 2022

Published March 2022

Join us Mar 23 at 2ET as our entire A2CPS consortium gathers onscreen. Learn more about this groundbreaking research effort - plus invited talks from Yarimar Carrasquillo, Ted Price, and Vivianne Tawfik.

Register Now

Acute to Chronic Pain Signatures Investigator Awarded NIH Funding

Published November 2021

Congratulations to Acute to Chronic Pain Signatures (A2CPS) Consortium member Giovanni Berardi, DPT, PhD, who was recently awarded funding from the National Institutes of Health’s HEAL (Helping to End Addiction Long-termSM) Initiative. The NIH HEAL InitiativeSM is aimed at improving prevention and treatment strategies for both opioid abuse and chronic pain.

New Multisite Clinical Center

Published December 2020

A group from the University of Michigan has been chosen to lead the second A2CPS Multisite Clinical Center. They will study 1,800 individuals scheduled for thoracic surgery.

Welcome to the A2CPS team!

2020 American Association for Cancer Research (AACR) Team Science Award

Published September 2020

Dr. Ari Kahn (DIRC) has been selected to receive the 2020 American Association for Cancer Research (AACR) Team Science Award. The award recognizes his pivotal contributions to the establishment and success of the Cancer Genome Atlas project.

Congratulations, Dr. Kahn!